Free radical mediated oxidative stress plays an important role in the functional impairments of brain and linked to neuronal cell death in certain neurodegenerative disorders [1]. However, brain cells possess many defense mechanisms against reactive oxygen species (ROS). ROS (superoxide radical, O2 -; hydrogen peroxide, H2O2; hydroxyl radical, OH-), are mainly produced in mitochondria. Sometimes it can be inadequate and may lead to oxidative stress in which the production of ROS befuddles the antioxidant defenses of the organism [2]. Reports indicate that oxygen derived radicals are implicated in lipid peroxidation (LPO) events, and are critical in neuronal injury as brain may be particularly vulnerable to oxidative stress because of PUFAs, which are particularly susceptible to free radicals mediated damage [2]. Parkinson’s disease (PD) is the second most common neurodegenerative disorder and it is characterized by the preferential degeneration of dopaminergic neurons in the substant